Antimicrobial activity of the plant Azadirachta indica (indian nim) – an integrative review.

Authors

  • Elon Faculdade de Enfermagem Nova Esperança de Mossoró
  • Cândida Maria Soares de Mendonça Universidade Federal do Rio Grande do Norte
  • Luanne Eugênia Nunes Universidade Federal de Pernambuco
  • Ítalo Diego Universidade Federal do Rio Grande do Norte

DOI:

https://doi.org/10.48017/dj.v7i4.2350

Keywords:

Azadirachta indica, Nim indiano, atividade antimicrobiana, metabólitos secundários

Abstract

Azadirachta indica, popularly known as Indian neem, is an exotic plant from the Asian continent, which has great therapeutic potential. Indian neem has Azadirachtin as its main secondary metabolite, which is one of the main responsible for its therapeutic action. Currently, neem has been the subject of several researches by the pharmaceutical industry both in the field of cosmetics, medicinal uses and also in pest control. Therefore, the objective of this work was to carry out an integrative review in order to identify the antimicrobial activity of this plant. Therefore, we sought to analyze which metabolites present in the plant would contribute to the action researched in this work, as well as for which pathologies it is used according to ethnobotanical studies. In this work, articles from the main available research sources were used. The following descriptors were used to search for articles: ‘‘Azadirachta indica’’, ‘‘antibacterial’’ action, ‘‘antimicrobial’’. The time frame for searching the files corresponded to the last ten years. The data were analyzed in a qualitative way, aiming at an answer to the proposed question. The results obtained in this study show that Indian neem has a relevant antimicrobial activity and has the potential to become a therapeutic alternative in the treatment of resistant microorganisms. However, more studies should be done in order to have a better theoretical basis regarding the antimicrobial activity of the plant.

Metrics

Metrics Loading ...

References

Adegbola, P. I., Semire, B., Fadahunsi, O. S., & Adegoke, A. E. (2021). Molecular docking and ADMET studies of Allium cepa, Azadirachta indica and Xylopia aethiopica isolates as potential anti-viral drugs for Covid-19. VirusDisease, 32(1), 85–97. https://doi.org/10.1007/s13337-021-00682-7.

Amede, S. C., Ribeiro, A. G., Rezende, M. H., & Faria, M. T. (2015). Morfo-anatomia e histoquímica foliar de Azadirachta indica A. JUSS (Neem) (Meliaceae), cultivadas em goiás. Revista Uniaraguaia, 7(7), 65–89. http://www.faculdadearaguaia.edu.br/sipe/index.php/REVISTAUNIARAGUAIA/article/view/327.

Beraldo, J. I., de Oliveira Bernardi, N., Meurer, M., Costa, G. M., & Arantes, V. P. (2015). Estudo da atividade antifúngica de extratos vegetais de Azadirachta indica frente a cepa padrão de Candida albicans ATCC 10231. Arquivos de Ciências da Saúde da UNIPAR, 19(1)

Bernardi, N. de O., Meurer, M., & Arantes, V. P. (2012). Estudo da atividade antibacteriana de extratos vegetais de Azadirachta indica “Neem” frente a cepa padrão de Streptococcus pyogenes ATCC 19615. Arq. Ciências Saúde UNIPAR, 117–122. https://pesquisa.bvsalud.org/portal/resource/pt/lil-761416

Blum, F. C., Singh, J., & Merrell, D. S. (2019). In vitro activity of neem (Azadirachta indica) oil extract against Helicobacter pylori. Journal of Ethnopharmacology, 232, 236–243. https://doi.org/10.1016/j.jep.2018.12.025

Candolle, A. P. (1824) Prodromus systematis naturalis Regni Vegetabilis, 1: 619-626.

Candolle, C. (1878a) Meliaceae. In: Martius CFP & Eichler AG (eds.) Flora brasiliensis Frid. Fleischer, Lipsiae. Vol. 11, pars 1, tab. 50-65, pp. 165-228.

Candolle, C. (1878b) Meliaceae. In: Candolle A & Candolle C. Monographiae Phanerogamarum 1: 419-758.

Dwivedi, V. D., Bharadwaj, S., Afroz, S., Khan, N., Ansari, M. A., Yadava, U., Tripathi, R. C., Tripathi, I. P., Mishra, S. K., & Kang, S. G. (2020). Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition. Journal of Biomolecular Structure and Dynamics, 1–14. https://doi.org/10.1080/07391102.2020.1734485.

Durand, G. A., Raoult, D., & Dubourg, G. (2019). Antibiotic discovery: history, methods and perspectives. International journal of antimicrobial agents, 53(4), 371-382.

Silva, R. S. (2019). A importância do profissional farmacêutico no controle à automedicação: uma revisão integrativa. Faculdade Nova Esperança de Mossoró (Facene/RN), curso de farmácia http://www.sistemasfacenern.com.br/repositorio/admin/acervo/8b5c05cc7515b796360a6d9504afa978.pdf

Faccin-Galhardi, L. C., Aimi Yamamoto, K., Ray, S., Ray, B., Carvalho Linhares, R. E., & Nozawa, C. (2012). The in vitro antiviral property of Azadirachta indica polysaccharides for poliovirus. Journal of Ethnopharmacology, 142(1), 86–90. https://doi.org/10.1016/j.jep.2012.04.018.

Garcia, R. Á., Juliatti, F. C., Barbosa, K. A. G., & Cassemiro, T. A. (2012). Atividade antifúngica de óleo e extratos vegetais sobre Sclerotinia sclerotiorum. Biosci. J. (Online), 48–57. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-912346.

Galeane, M. C. [UNESP. (2015). Prospecção fitoquímica de ativos em extratos e frações originados de folhas de Azadirachta indica A. JUSS. visando atividade antimicrobiana. Aleph, 66 f. : tabs, figs. https://repositorio.unesp.br/handle/11449/134011.

Guchhait, K. C., Manna, T., Barai, M., Karmakar, M., Nandi, S. K., Jana, D., Dey, A., Panda, S., Raul, P., Patra, A., Bhattacharya, R., Chatterjee, S., Panda, A. K., & Ghosh, C. (2022). Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts. BMC Complementary Medicine and Therapies, 22(1). https://doi.org/10.1186/s12906-022-03513-4.

Kushwaha, P. P., Singh, A. K., Bansal, T., Yadav, A., Prajapati, K. S., Shuaib, M., & Kumar, S. (2021). Identification of Natural Inhibitors Against SARS-CoV-2 Drugable Targets Using Molecular Docking, Molecular Dynamics Simulation, and MM-PBSA Approach. Frontiers in Cellular and Infection Microbiology, 11. https://doi.org/10.3389/fcimb.2021.730288.

Maia, D. R. (2021). Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano. Repositorio.ufrn.br. https://repositorio.ufrn.br/handle/123456789/38286.

Medeiros, A. J. D. D., Feijó, F. M. C., Santos, C. S., Lucas, C. R., & Melo, D. D. D. M. B. D. (2012, August). Avaliação da atividade antimicrobiana das plantas Spondias purpurea L., Spondias mombin L., e Azadirachta indica A. sobre cepas isoladas de caprinos com aptidão leiteira. In VII CONNEPI-Congresso Norte Nordeste de Pesquisa e Inovação.

Menezes, R. M. de S., Lima, J. R. de, Santos, D. de S., Santos, J. C. dos, & Viana, A. C. (2021). Extração, caracterização, prospecção por CG-EM e efeito bactericida do óleo essencial de NIM (Azadirachta indica). Research, Society and Development, 10(15), e507101523154. https://doi.org/10.33448/rsd-v10i15.23154.

Naeem, S., Siddique, A. B., Zahoor, M. K., Muzammil, S., Nawaz, Z., Waseem, M., Yasmin, A., & Asif Zahoor, M. (2021). In vitro efficacy of Azadirachta indica leaf extract against methicillin resistant Staphylococci isolated from skin infection. Pakistan Journal of Pharmaceutical Sciences, 34(6(Supplementary)), 2303–2308. https://pubmed.ncbi.nlm.nih.gov/35039267/.

Neglo, D., Adzaho, F., Agbo, I. A., Arthur, R., Sedohia, D., Tettey, C. O., & Waikhom, S. D. (2022). Antibiofilm Activity of Azadirachta indica and Catharanthus roseus and Their Synergistic Effects in Combination with Antimicrobial Agents against Fluconazole-Resistant Candida albicans Strains and MRSA. Evidence-Based Complementary and Alternative Medicine, 2022, e9373524. https://doi.org/10.1155/2022/9373524

Nesari, T. M., Bhardwaj, A., ShriKrishna, R., Ruknuddin, G., Ghildiyal, S., Das, A., ... & Barde, M. (2021). Neem (Azadirachta indica A. Juss) Capsules for Prophylaxis of COVID-19 Infection: A Pilot, Double-Blind, Randomized Controlled Trial. Altern. Ther. Health Med, 23, 1-8.

Neto, I. F. da S., Leite, I. B., Aguiar, A. M., & Silva, M. R. (2020). Bioprospecção farmacológica: avaliação fitoquímica do Nim indiano (Azadirachta indica A. Juss.). Undefined. https://www.semanticscholar.org/paper/BIOPROSPEC%C3%87%C3%83O-FARMACOL%C3%93GICA%3A-AVALIA%C3%87%C3%83O-FITOQU%C3%8DMICA-Neto-Leite/5fd423de921936229236818a79bfb58f95c3915b.

Nigussie, D., Davey, G., Legesse, B. A., Fekadu, A., & Makonnen, E. (2021). Antibacterial activity of methanol extracts of the leaves of three medicinal plants against selected bacteria isolated from wounds of lymphoedema patients. BMC Complementary Medicine and Therapies, 21(1). https://doi.org/10.1186/s12906-020-03183-0.

Nogueira, Pedro A. F. et al. Estudo dos impactos ambientais causados pelo plantio exacerbado da planta Nim (Azadirachta indica) na cidade de Encanto-RN. 69ª Reunião Anual da SBPC - 16 a 22 de julho de 2017 - UFMG - Belo Horizonte/MG.

Okoh, S. O., Okoh, O. O., & Okoh, A. I. (2019). Inhibitory effects of Azadirachta indica secondary metabolites formulated cosmetics on some infectious pathogens and oxidative stress radicals. BMC Complementary and Alternative Medicine, 19(1). https://doi.org/10.1186/s12906-019-2538-0.

Paes, J. B., Souza, A. D. D., Lima, C. R. D., & Souza, P. F. D. (2012). Eficiência dos óleos de nim (Azadirachta indica A. Juss.) e mamona (Ricinus communis L.) na resistência da madeira de sumaúma (Ceiba pentandra (L.) Gaerth.) a fungos xilófagos em simuladores de campo. Ciência Florestal, 22(3), 617-624.

Prakash, D., Saini, M., Tyagi, N., Madan, A., & Dutta, R. (2021). A Mystical plant Azadirachta indica used as phytomedicine: state-of-the-art. Plant cell biotechnology and molecular biology, 575–583. https://www.ikprress.org/index.php/PCBMB/article/view/7356.

Queiroz, T. N., Pascuali, L. C., do Prado Silva, A. C., Porto, A. G., & Carvalho, J. W. P. (2020). Extratos e óleos essenciais como alternativa no controle de Sclerotinia sclerotiorum e Sclerotium rolfsii isolados de soja (Glycine max L.). Revista em Agronegócio e Meio Ambiente, 13(2), 737-753.

Quelemes, P. V., Perfeito, M. L., Guimarães, M. A., dos Santos, R. C., Lima, D. F., Nascimento, C., ... & Leite, J. R. S. (2015). Effect of neem (Azadirachta indica A. Juss) leaf extract on resistant Staphylococcus aureus biofilm formation and Schistosoma mansoni worms. Journal of ethnopharmacology, 175, 287-294.

Santos, N. de Q. (2004). A resistência bacteriana no contexto da infecção hospitalar. Texto & Contexto - Enfermagem, 13(spe), 64–70. https://doi.org/10.1590/s0104-07072004000500007

Saquib, S. A., AlQahtani, N. A., Ahmad, I., Arora, S., Asif, S. M., Javali, M. A., & Nisar, N. (2021). Synergistic antibacterial activity of herbal extracts with antibiotics on bacteria responsible for periodontitis. The Journal of Infection in Developing Countries, 15(11), 1685–1693. https://doi.org/10.3855/jidc.14904.

Silva, M. B., Feitosa, A. O., Lima, I. G., Bispo, J. R., Santos, A. C. M., Moreira, M. S., ... & Queiroz, A. C. (2022). Antarctic organisms as a source of antimicrobial compounds: a patent review. Anais da Academia Brasileira de Ciências, 94.

Singaravelu, S., Sankarapillai, J., Chandrakurumai, A. S. Pinha, P. (2019). Effect of Azadirachta indica crude bark extracts concentrations Against gram-positive and gram-negative bacterial pathogens. Journal of Pharmacy & BioAllied Sciences, 11(1), 33-37.

Subapriya, R., & Nagini, S. (2005). Medicinal properties of neem leaves: a review. Current Medicinal Chemistry-Anti-Cancer Agents, 5(2), 149-156.

Ugboko, H. U., Nwinyi, O. C., Oranusi, S. U., Fatoki, T. H., & Omonhinmin, C. A. (2020). Antimicrobial Importance of Medicinal Plants in Nigeria. The Scientific World Journal, 2020, 1–10. https://doi.org/10.1155/2020/7059323.

Xu, J., Song, X., Yin, Z. Q., Cheng, A. C., Jia, R. Y., Deng, Y. X., Ye, K. C., Shi, C. F., Lv, C., & Zhang, W. (2012). Antiviral activity and mode of action of extracts from neem seed kernel against duck plague virus in vitro. Poultry Science, 91(11), 2802–2807. https://doi.org/10.3382/ps.2012-02468.

Published

2022-10-10

How to Cite

Elon, Mendonça, C. M. S. de ., Nunes, L. E. ., & Ítalo Diego. (2022). Antimicrobial activity of the plant Azadirachta indica (indian nim) – an integrative review. Diversitas Journal, 7(4). https://doi.org/10.48017/dj.v7i4.2350

Most read articles by the same author(s)