LDLR rs2228671 gene polymorphism and relationship with the development of familial hypercholesterolemia and obesity in military police officers officers
DOI:
https://doi.org/10.48017/dj.v8i4.2682Keywords:
LDLR gene, familial hypercholesterolemia, genetic polymorphismAbstract
The polymorphism of the LDLR gene (LDL cholesterol receptor) is associated with lipid alterations, such as familial hypercholesterolemia (FH), caused by mutations in the genes that produce LDLR catabolic and uptake proteins. The objective of this study was to associate the polymorphism of the LDLR gene rs2228671 (C/T) with dyslipidemia in military police officers in the State of Goiás. The case-control study evaluated samples from 200 military police officers, by lipid profile measurement and by qPCR (real-time polymerase chain reaction) to identify possible associations between dyslipidemias, FH and LDLR gene polymorphism. Of the military police officers, 93% were male. In the lipid profile, 58% belonged to the group with the presence of a degree/class of dyslipidemia. The genetic analysis of the case group, the LDLR gene showed 68.1% of the CC genotype, 19.8% TC and 12.1% TT. In the control group, the genotype was CC in 82.1%, CT in 14.3% and TT in 3.6%. Lipid and BMI parameters were analyzed between the case and control groups. The dominant heterozygous genotype CT, 4.4% of the police officers exhibited TC ≥310 mg/dL with a positive diagnosis of FH and 95.6% CT <310 mg/dL, representing a probable diagnosis of FH. In the TT genotype, 100.0% of the police officers had TC <310 mg/dL, with a negative diagnosis for FH. The C allele of the LDLR rs2228671 gene in CC-dominant homozygosity and CT-dominant heterozygosity presents a high risk for the development of FH and obesity compared to the T allele.
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References
ABESO. Associação Brasileira para o Estudo da Obesidade e da Sindrome Metabólica. (2016). Diretrizes brasileiras de obesidade. https:abeso.org.br/wp-content/uploads/2019/12/diretrizes-downloaddiretrizes-brasileiras-de-obesidade-2016.pdf.
BRASIL. Ministério da Saúde. (2021). Secretaria de Vigilância em Saúde. Departamento de Análise em Saúde e Vigilância de Doenças Não Transmissíveis. Plano de Ações Estratégicas para o Enfrentamento das Doenças Crônicas e Agravos não Transmissíveis no Brasil 2021-2030. – Brasília: Ministério da Saúde.
BAYNES, J. W.; DOMINICZAK, M.H. (2011). Bioquímica Médica. [Elsevier]. (3th ed.)
DA SAÚDE. (2008). Diretrizes e Recomendações para o Cuidado Integral de Doenças Crônicas Não-Transmissíveis. https://bvsms.saude.gov.br/bvs/publicacoes/diretrizes_recomendacoes_cuidado_doencas_cronicas.pdf.
DO NASCIMENTO, V. M.S.; SOARES, N.M.M.; OLIVEIRA, D.P.M.; TELE, L.L.; OLIVEIRA, L.A.S.; SILVA, J.S. (2021). NÍVEL DE ATIVIDADE FÍSICA E SAÚDE MENTAL EM POLICIAIS MILITARES DE SERGIPE, BRASIL. In: Congresso Internacional em Saúde.
GARBARINO, S. (2014). Police and military. Sleepiness and human impact assessment, 4(2), 159-168.
FALUD, A.A.; IZAR, M.C.O.; SARAIVA, J.F.K.; CHACRA, A.P.M.; BIANCO, H.T.; AFIUNE, N.A.; BERTOLAMIM, A.P.; SPOSITO, A.C.; CHAGAS, A.C.P.; CASELLA-FILHO, A.; SIMAO, A.F.; ALENCAR, F.A.C. (2017). Atualização da diretriz brasileira de dislipidemias e prevenção da aterosclerose–2017. Arquivos brasileiros de cardiologia, 109, 1-76.
FERENCE, B.A; GINSBERG, H.N., GRAHAM, I., RAY, K.K., PACKARD, C.J., BRUCEKT, E., HEGELE, R.A., KRAUSS, R.M., RAAL, F.J., SCHUNKERT, H., et al. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinicalstudies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 38(2), 2459-2472.
FRIGHETTO, M. (2020). AVALIAÇÃO DE SAÚDE EM POLICIAIS MILITARES DE UM MUNICÍPIO DO MEIO OESTE CATARINESE. Anuário Pesquisa e Extensão Unoesc Videira, 5(2), e24695-e24695.
IZAR, M.C.O.; BERTOLAMI, A.; FILHO, R.D.S.; LOTTENBERG, A.M.; ASSAD, M.H.V.; SARAIVA, J.F.K.; CHACRA, A.P.M.; MARTINEZ, T. L.R.; BAHIA, L.R.; FONSECA, F.A.H.; FALUDI, A.A.; SPOSITO, A.C.; COUTINHO, E.R.; NETO, J.R.F. KATO, J.T. (2021). Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar–2021. Arquivos Brasileiros de Cardiologia, 117, 782-844.
JHA, C.K. MIR, R.; BANU, S.; ELFAKI, I.; CHAHAL, S.M.S. (2020). Heterozygosity in LDLR rs2228671 and rs72658855 Gene is Associated with Increased Risk of Developing Coronary Artery Disease in India – A Case-Control Study. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 20(3), 388-399.
LEIGH, S.; FUTEMA, M., WHITTALL, R., TAYLOR-BEADLING, A., WILLIAMS, M., DEN DUNNEN, J.T., HUMPHRIES, S.E., (2017). The UCL low-density lipoprotein receptor gene variant database: Pthogenicity update. J Med Genet. 54(1), 217-223.
LINSEL-NITSCHKE, P.; GOTZ, A. ERDMANN, J.; BRAENNE, I.; BRAUND, P.; HENGTENBERG, C.; STARK, K.; FISCHER, M.; SCHREIBER, S.; NOUR, ED.; MOKHARI, E.; SCHAEFER A.; MANGINO, M.; LIEB, W.; LAMINA, C.; ZIEGLER I.; KRONENBERG, F. (2008). Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease — a Mendelian randomisation study. Plos One, 3(8), .e2986.
LIUINSEL- X.Q.; XIE, Y.N.; BAI, Z. J.; WANG, W. (2006). Mental stress and its related factors in armed police soldiers at high altitude. Chinese Journal of Clinical Rehabilitation, 10(30), 60-62.
MAGNAVITA, N.; GARBARINO, S. (2017). Sleep, health and wellness at work: a scoping review. International journal of environmental research and public health, 14(11), 1347-1368.
MARTINELI, N., GIRELLI, D., LUNGHI, B., PINOTTI, M., MARCHETTI, G., MALERBA, G., PIGNATTII, P.F., CORROCHER, R., OLIVIERI, O., BERNARDI, F. (2010). Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile. Blood. 116, 5688-5697.
MION, J.R.; NOBRE, F. G.; AMODEO, C.; JUNIOR, O. A.; PRAXEDES, J. N.; MACHADO, C.A.; PASCOAL, I.; MAGALHÃES, LC. (2004). IV Diretrizes brasileiras de hipertensão arterial. Arquivos Brasileiros de cardiologia, 82, 1-57.
OLIVEIRA, K.L.S.; SANTOS, L.M. (2010). Luana Minharo dos. Percepção da saúde mental em policiais militares da força tática e de rua. Sociologias, 12(2), 224-250.
PAULINO, F.R.; LOURINHO, L.A. (2014). O adoecimento psicológico do policial militar do Ceará. Revista trabalho e sociedade, Fortaleza, 2(2), 58-77.
POURZARGHAM, P.; ATAOLAHI M.; FOULADSERESHT, S.; KHOSROPANAH, M.; DOROUDCHI, M. (200). Association of anteroseptal hypokinesia after myocardial infarction with LDLR variation: A cross-sectional case-control study. Journal of Experimental and Clinical Medicine, 37(3), 87-95.
SANDHU, M.S., WATERWORTH, D.M., DEBENHAM, S.L., WHEELER, E., PAPAPDAKIS, K., ZHAO, J.H., SONG, K., YUAN, X., JOHNSON, T., ASHFORD, S., INOUYE, M., LUBEN, R., SIMS, M., HADLEY, D., MCARDLE, W., BARTER, P. (2008). LDL-cholesterol concentrations: A genome-wide association study. Lancet. 371, 483-491.
RUGHI, A.L.; BASSO, C.; SCHUCH, N. J. (2021). Síndrome Metabólica e Fatores de Risco Cardiovascular em Policiais Militares: uma revisão da literatura. Disciplinarum Scientia| Saúde, 22(1), 123-133.
TAYLOR, Y.; MERAT, N.; JAMSON, S. (2019). The Effects of Fatigue on Cognitive Performance in Police Officers and Staff During a Forward Rotating Shift Pattern. Saf Health Work, 10(1), 67-74.
YE, H., ZHAO, Q., HUANG, Y., WANG, L., LIU, H., WANG, C., DAI, D., XU, L., YE, M., DUAN, S., 2014. Meta-analysis of low density lipoprotein receptor (LDLR) rs2228671 polymorphism and coronary heart disease. Biomed. Res. Int. 2014, 564940.
WILLIAMS, R.R.; HUNT, S.C.; SCHUMACHER, M.C.; HEGELE, R.A.; LEPPERT, M.F.; LUDWIG, E.H.; HOPKINS, P.N. (1993). Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. Am J Cardiol, 72(2), 171-176.
XAVIR, H.T.; IZAR, M.C.; NETO, F.J.R.; ASSAD, M.H.; ROCHA, V.Z.; SPOSITO, A.C.; FONSECA, F.A.; SANTOS, J.E.; SANTOS, R.D.; BERTOLAMI, M.C.; FALUDI, A.A.; MARTINES, T.L.R.; DIAMENT, J.; GUIMARAES, A.; FORTI, N.A.; MORI-GUCHI, E.; CHAGAS, A.C.P.; COELHO, O.R.; RAMIRES, J.A.F. (2013). V Diretriz brasileira de dislipidemias e prevenção da aterosclerose. Arquivos brasileiros de cardiologia, 101(3), 1-20.
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