Uso de aditivos e compostos secundários na nutrição de caprinos e ovinos: revisão de literatura

Autores

DOI:

https://doi.org/10.48017/dj.v11i1.3624

Palavras-chave:

Pequenos ruminantes, Substitutos de antibióticos, Saúde ruminal

Resumo

Com o impedimento do uso dos antibióticos na produção animal como promotores de crescimento devido aos efeitos colaterais e à presença de resíduos em produtos de origem animal, existe uma necessidade para o desenvolvimento e utilização de substâncias alternativas para a substituição dos antibióticos. Os aditivos alimentares e compostos secundários provenientes de extratos de plantas têm sido utilizados na ração animal como substituintes dos antibióticos, exercendo funções terapêuticos e profiláticos. O objetivo desta revisão é apresentar um resumo abrangente sobre o uso de aditivos e compostos secundários na nutrição de pequenos ruminantes, destacando seu papel como estratégias nutricionais eficazes para a melhoria do desempenho e da saúde animal, além dos desafios no desenvolvimento de alternativas sustentáveis, seguras e acessíveis. Contudo, a eficácia dos aditivos na alimentação animal, depende de múltiplos fatores, como o tipo de dieta, o estágio fisiológico e a categoria animal, além das condições de manejo. Assim, a escolha e o uso adequado dos aditivos devem ser baseados em evidências científicas e ajustados às particularidades de cada sistema, visando sempre o equilíbrio entre produtividade, bem-estar animal e responsabilidade ambiental.

Métricas

Carregando Métricas ...

Biografia do Autor

Joanigo Fernando Simão, Universidade Federal do Vale do São Francisco. Petrolina, PE, Brasil

0009-0004-5663-4958; Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil. joanigosimao@gmail.com

Marcelo Caique Félix Rodrigues, Universidade Federal do Vale do São Francisco. Petrolina, PE, Brasil

0000-0002-0465-2431; Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil. zoot.marcelofelix@gmail.com

Ailton Batista Pereira, Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil

0000-0001-6360-1389; Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil. veter.ailton@gmail.com

Elves Oliveira da Silva, Universidade Federal do Vale do São Francisco. Petrolina, PE, Brasil

0000-0001-6173-8517; Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil. elves.senar@gmail.com

Érika Karoline de Oliveira Aureliano, Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil

0009-0003-3875-2494; Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil. erikakarolline.ek@gmail.com

Glayciane Costa Gois, Universidade Federal do Maranhão. Chapadinha, Maranhão (MA), Brasil

0000-0002-4624-1825; Universidade Federal do Maranhão. Chapadinha, Maranhão (MA), Brasil.  glayciane_gois@yahoo.com.br

Fleming Sena Campos, Universidade Estadual do Sudoeste da Bahia. Itapetinga, Bahia (BA), Brasil

0000-0001-9027-3210; Universidade Estadual do Sudoeste da Bahia. Itapetinga, Bahia (BA), Brasil. fleming.campos@uesb.edu.br

Cleyton de Almeida Araújo, Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil

0000-0003-3636-2890; Universidade Federal do Vale do São Francisco. Petrolina, Pernambuco (PE), Brasil. cleyton.araujo@univasf.edu.br

Referências

Adamczyk, B., Simon, J., Kitunen, V., Adamczyk, S., & Smolander, A. (2017). Tannins and their complex interaction with different organic nitrogen compounds and enzymes: Old paradigms versus recent advances. ChemistryOpen, 6, 610 – 614. DOI: 10.1002/open.201700113

Adjei‐Fremah, S., Worku, M., & Ibrahim, S. (2023). Immune‐Modulation and Gut Microbiome. In: N. Srivastava, S. Ibrahim, J. Chattopadhyay, M. Arbab (orgs.), The Gut Microbiota in Health and Disease. (179-191). John Wiley & Sons, Ltd. DOI: 10.1002/9781119904786.ch16

Alhidary, I. A., Abdelrahman, M. M., & Elsabagh, M. (2019). A comparative study of four rumen buffering agents on productive performance, rumen fermentation and meat quality in growing lambs fed a total mixed ration. Animal, 13(10), 2252-2259. DOI: 10.1017/S1751731119000296

Anadón, A., Martínez-Larrañaga, M. R., & Martínez, M. A. (2006). Probiotics for animal nutrition in the European Union. Regulation and safety assessment. Regulatory toxicology and pharmacology, 45(1), 91-95. DOI: 10.1016/j.yrtph.2006.02.004

Angelakis, E. (2017). Weight gain by gut microbiota manipulation in productive animals. Microbial Pathogenesis, 106, 162-170. DOI: 10.1016/j.micpath.2016.11.002

Arriola, K. G., Oliveira, A. S., Ma, Z. X., Lean, I. J., Giurcanu, M. C., & Adesogan, A. T. (2017). A meta-analysis on the effect of dietary application of exogenous fibrolytic enzymes on the performance of dairy cows. Journal of Dairy Science, 100(6), 4513-4527. DOI: 10.3168/jds.2016-12103

Aşici, G. S. E., Çağli, A., Çoğan, H., Kiral, F., & Yilmaz, M. (2024). Effect of propolis applied to goat kids at weaning period on heat shock protein genes. Harran Üniv Vet Fak Derg, 13(2), 84-92. DOI: 10.31196/huvfd.1451671

Assis, T. S. (2019). Utilização de volumoso extrusado contendo diferentes aditivos na alimentação de ovinos. [Dissertação de Mestrado em Ciências Veterinárias, Universidade Federal de Uberlândia]. 72f. http://dx.doi.org/10.14393/ufu.di.2019.1219.

Bąkowski, M., & Kiczorowska, B. (2021). Probiotic microorganisms and herbs in ruminant nutrition as natural modulators of health and production efficiency–a review. Annals of Animal Science, 21(1), 3-28. DOI: 10.2478/aoas-2020-0081

Baungratz, A. R, Venturini, T., & Maeda, E. M. (2024). Aditivos utilizados na nutrição de ruminantes: características e particularidades. Iguazu science, 2(3), 48-59.

Belanche, A., Ramos-morales, E., & Newbold, C. J. (2015). In vitro screening of natural feed additives from crustaceans, diatoms, seaweeds and plant extracts to manipulate rumen fermentation. Journal Science Food Agricuture, 96(9), 3069-3078. DOI: 10.1002/jsfa.7481

Bodas, R., Prieto, N., García-González, R., Andrés, S., Giráldez, F. J., & López, S. (2012). Manipulation of rumen fermentation and methane production with plant secondary metabolites. Animal Feed Science and Technology, 176(1-4), 78-93. DOI: 10.1016/j.anifeedsci.2012.07.010

Cais-Sokolinska, D., Kaczynski, Ł. K., & Bielska, P. (2022). Inhibition of galactooligosaccharide (GOS) degradation in high-heat-treated goat’s milk as a raw material for functional dairy products. Applied Science, 12, e11639. DOI: 10.3390/app122211639

Cangiano, L. R., Yohe, T. T., Steele, M. A., & Renaud, D. L. (2020). Invited Review: Strategic use of microbial-based probiotics and prebiotics in dairy calf rearing. Applied Animal Science, 36(5), 630-651. DOI: 10.15232/aas.2020-02049

Cavendish, R. L., Santos, J. S., Neto, R. B., Paixão, A. O., Oliveira, J. V., Araujo, E. D., Berretta E. S. A. A., Thomazzi, M. S., Cardoso J. C., & Gomes, M. Z. (2015). Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. Journal of Ethnopharmacology, 173, 127-133. DOI: 10.1016/j.jep.2015.07.022

Charalampopoulos, D., & Rastall, R. A. (2009). Ciência e tecnologia de prebióticos e probióticos (Vol. 1). Springer Science & Business Media.

Cheng, G., Hao, H., Xie, S., Wang, X., Dai, M., Huang, L., & Yuan, Z. (2014). Antibiotic alternatives: the substitution of antibiotics in animal husbandry? Frontiers in Microbiology, 5, 1 – 15. DOI: 10.3389/fmicb.2014.00217

Chumchalová, J., & Šmarda, J. (2003). Human tumor cells are selectively inhibited by colicins. Folia Microbiologica, 48(1), 111-115, DOI: 10.1007/BF02931286

Chung, Y. H., Zhou, M., Holtshausen, L., Alexander, T. W., McAllister, T. A., Guan, L. L., Oba, M., & Beauchemin, K. A. (2012). A fibrolytic enzyme additive for lactating Holstein cow diets: ruminal fermentation, rumen microbial populations, and enteric methane emissions. Journal of Dairy Science, 95(3), 1419-1427. DOI: 10.3168/jds.2011-4552

Cotter, P D., Ross, R. P., & Hill, C. (2013). Bacteriocins—a viable alternative to antibiotics? Nature Reviews Microbiology, 11(2), 95-105. DOI: 10.1038/nrmicro2937

Danieli, B., & Schogor, A. L. B. (2020). Uso de aditivos na nutrição de ruminantes: Revisão. Veterinaria e Zootecnia, 27, 1-13.

De Carvalho, A. A. T., VanettI, M. C. D., & Mantovani, H. C. (2008). Bovicin HC5 reduces thermal resistance of Alicyclobacillus acidoterrestris in acidic mango pulp. Journal of applied microbiology, 104(6), 1685-1691. DOI: 10.1111/j.1365-2672.2007.03710.x

De Souza, F. M., Lopes, F. B., Eifert, E. D. C., Magnabosco, C. D. U., Costa, M., & Brunes, L. C. (2016). Extratos vegetais como moduladores da fermentação ruminal. Planaltina, DF: Embrapa Cerrados. 42p. https://www.infoteca.cnptia.embrapa.br/infoteca/bitstream/doc/1068159/1/Doc331.pdf . Acesso em: 14/05/2025

Deegan, L. H., Cotter, P. D., Hill, C., & Ross, P. (2006). Bacteriocins: biological tools for bio-preservation and shelf-life extension. International Dairy Journal, 16(9), 1058-1071. DOI: 10.1016/j.idairyj.2005.10.026

Elghandour, M. M. Y., Salem, A. Z. M., Castañeda, J. S. M., Camacho, L. M., Kholif, A. E., & Chagoyán, J. C. V. (2015). Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants. Journal of Integrative Agriculture, 14(3), 526–533. DOI: h10.1016/S2095-3119(14)60834-0

El-Nile, A. E., Elaza, M. A., Soltan, Y. A., Elkomy, A. E., El-Zaiat, H. M., Sallam, S. M. A., & El-Azrak, K. E.-D. (2023). Nano and natural zeolite feed supplements for dairy goats: Feed intake, ruminal fermentation, blood metabolites, and milk yield and fatty acids profile. Animal Feed Science and Technology, 295, e115522. DOI: 10.1016/j.anifeedsci.2022.115522

El-Zaiat, H. M, Al-Marzooqi, W., & Al-Kharousi, K. (2025). Effects of chitosan-based additive on rumen fermentation and microbial community, nutrients digestibility and lactation performance in goats. Journal of Animal Physiology and Animal Nutrition, 109 (2), 338-349. DOI: 10.1111/jpn.14057

Estrada-Angulo, A., Escobedo-Gallegos, L. G., Arteaga-Wences, Y. J., Ramos-Méndez, J. L., Quezada-Rubio, J. A., Vizcarra-Chávez, C. A., Valdés-García, Y. S., Barreras, A., Zinn, R. A., & Plascencia, A. (2023). Effect of combining the ionophore monensin with natural antimicrobials supplemented in the last phase of finishing of lambs: growth performance, dietary energetics, and carcass characteristics. Animals, 13, e2547. DOI: 10.3390/ani13162547

FAO/WHO. (2002). Guidelines for the evaluation of probiotics in food. Report of a joint fao/who working group on drafting guidelines for the evaluation of probiotics in food. http://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf

Felício, I. M., Cavalcanti, A. M. T., Baranger, K., Oliveira Junior, R. G., Poirot, B., Picot, L., Cavalcante, F. A. (2025). Brazilian propolis: Chemical composition, regional variability, and bioactive potential. Fitoterapia, 185, e106687. DOI: 10.1016/j.fitote.2025.106687

Fonseca, N. V. B., Silva Cardoso, A., Granja-Salcedo, Y. T., Siniscalchi, D., Camargo, K. D. V., Dornellas, I. A., Silva, M. L. C., Vecchio, L. S. D., Grizotto, R. K. & Reis, R. A. (2024). Effects of condensed tannin-enriched alternative energy feedstuff supplementation on performance, nitrogen utilization, and rumen microbial diversity in grazing beef cattle. Livestock Science, 287, e105529. DOI: 10.1016/j.livsci.2024.105529

Fotso, S. C., Kenmogne, S. B., Soloveva, M. I., Kuzmina, S. S., & Toze, F. A. A. (2025). Chemical composition and in vitro antifungal activity of Wild thyme (Thymus serpyllum L.) Lamiaceae and Reindeer lichen (Cladonia stellaris) Cladoniaceae from Yakutia (Russia). Pharmacological Research-Natural Products, 6, e100185. DOI: 10.1016/j.prenap.2025.100185

Freitas, A. B. I., Vilaça, L. E. G., Siqueira, M. T. S., Oliveira, K. A., Oliveira, M. R., Macedo Júnior, G. L., & Santana, A. G. (2023a). Parâmetros produtivos e comportamentais de cabritos alimentados com enzimas exógenas na dieta. Cadernos de Ciências Agrárias, 15, 01–10. DOI: 10.35699/2447-6218.2023.43886

Freitas, A. B. I., Vilaça, L. E. G., Siqueira, M. T. S., Oliveira, K. A., Sousa, L. F., & Macedo Júnior, G. L. (2023b). Consumo e metabólitos sanguíneos de cabritos alimentados com enzimas exógenas na dieta. Cadernos de Ciências Agrárias, 15, 01–13. DOI: 10.35699/2447-6218.2023.44725

Gaggìa, F., Mattarelli, P., & Biavati, B. (2010). Probiotics and prebiotics in animal feeding for safe food production. International Journal of Food Microbiology, 141, 15-28. DOI: 10.1016/j.ijfoodmicro.2010.02.031

Gelgelo, K., Kechero, Y., & Andualem, D. (2024). Seasonal and altitudinal dynamics in secondary metabolite composition of Commelina forage species in Konso zone, southern Ethiopia. PloS one, 19(11), e0314358. DOI: 10.1371/journal.pone.0314358

Gemeda, B. S., & Hassen, A. (2018). The potential of tropical tannin rich browses in reduction of enteric methane. Approaches in Poultry, Dairy & Veterinary Sciences, 2(3), 154-162. DOI: 10.31031/APDV.2018.02.000538

Georgalaki, M. D., Van den Berghe, E., Kritikos, D., Devreese, B., Van Beeumen, J., Kalantzopoulos, G., De Vuyst, L. & Tsakalidou, E. (2002). Macedocin, a food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198. Applied and Environmental Microbiology, 68(12), 5891-5903. DOI: 10.1128/AEM.68.12.5891-5903.2002

Ghimpeteanu, O. M., Pogurschi, E. N., Popa, D. C., Dragomir, N., Dragotoiu, T., Mihai, O. D. & Petcu, C. D. (2022). Antibiotic use in livestock and residues in food—a public health threat: A review. Foods, 11, e1430. DOI: 10.3390/foods11101430

Goiri, I., Oregui, L. M., & Garcia-Rodriguez, A. (2013). Use of chitosans to modulate ruminal fermentation of a 50:50 forage-to-concentrate diet in sheep, Journal of Animal Science, 88(2), 749–755. DOI: 10.2527/jas.2009-2377

Goiri, I., Oregui, L. M., & Garcia-Rodriguez, A. (2009). Dose–response effects of chitosans on in vitro rumen digestion and fermentation of mixtures differing in forage-to-concentrate ratios. Animal Feed Science and Technology, 151(3-4), 215-227. DOI: 10.1016/j.anifeedsci.2009.01.016

Guerreiro, O., Alves, S. P., Soldado, D., Cachucho, L., Almeida, J. M., Francisco, A., Santos-Silva, J., Bessa, R. J. B., & Jerónimo, E. (2020). Inclusion of the aerial part and condensed tannin extract from Cistus ladanifer L. in lamb diets – Effects on growth performance, carcass and meat quality and fatty acid composition of intramuscular and subcutaneous fat. Meat Science, 160, e107945. DOI: 10.1016/j.meatsci.2019.107945

He, M., Li, L., Wang, H., Yan, S., & Zhang, Y. (2019). Effects of high-grain diet with buffering agent on the hepatic metabolism in lactating goats. Frontiers in Physiology, 10, e661. DOI: 10.3389/fphys.2019.00661

Hess, H. D., Beuret, R. A., Lötscher, M., Hindrichsen, I. K., Machmüller, A., Carulla, J. E., Lascano, C. E., & Kreuzer, M. (2004). Ruminal fermentation, methanogenesis and nitrogen utilization of sheep receiving tropical grass hay-concentrate diets offered with Sapindus saponaria fruits and Cratylia argentea foliage. Animal Science, 79(1), 177-189. DOI: 10.1017/S1357729800054643

Hoang, K. V., Stern, N. J., & LIN, J. (2011). Development and stability of bacteriocin resistance in Campylobacter spp. Journal of Applied Microbiology, 111(6), 1544-1550. DOI: 10.1111/j.1365-2672.2011.05163.x

Hsieh, C. Y., Osaka, T., Moriyama, E., Date, Y., Kikuchi, J., & Tsuneda, S. (2015). Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum. Physiological reports, 3(3), e12327. DOI: 10.14814/phy2.12327

Huang, R., Ma, C., Zhang, F., & Wang, X. (2023). Effects of condensed tannins on bacterial and fungal communities during aerobic exposure of sainfoin silage. Plants, 12(16), 2967. DOI: 10.3390/plants12162967

Hutkins, R. W., Krumbeck, J. A., Bindels, L. B., Cani, P. D., Fahey Jr, G., Goh, Y. J., Hamaker B., Martens, E. C., Mills, D. A., Rastal, R. A., Vaughan, E. & Sanders, M. E. (2016). Prebiotics: why definitions matter. Current Opinion in Biotechnology, 37, 1-7. DOI: 10.1016/j.copbio.2015.09.001

Ivan, M., Koenig, K. M., Teferedegne, B., Newbold, C. J., Entz, T., Rode, L. M., & Ibrahim, M. (2004). Effects of the dietary Enterolobium cyclocarpum foliage on the population dynamics of rumen ciliate protozoa in sheep. Small Ruminant Research, 52(1-2), 81-91. DOI: 10.1016/S0921-4488(03)00230-X

Ivanova, S., Sukhikh, S., Popov, A., Shishko, O., Nikonov, I., Kapitonova, E., Krol, O., Larina, V., Noskova, S. & Babich, O. (2024). Medicinal plants: a source of phytobiotics for the feed additives. Journal of Agriculture and Food Research, 16, e101172. https://doi.org/10.1016/j.jafr.2024.101172

Jung, H. S., & Neuman, K. C. (2021). Surface modification of fluorescent nanodiamonds for biological applications. Nanomaterials, 11(1), e153. DOI: 10.3390/nano11010153

Kabiloglu, O., Abas, I., & Kocabagli, N. (2025). Effect of propolis extract on performance, health and immune parameters in lambs. Small Ruminant Research, 249, e107522. DOI: 10.1016/j.smallrumres.2025.107522

Kafilzadeh, F., Payandeh, S., Gómez-Cortés, P., Ghadimi, D., Schiavone, A., & Martínez Marín, A. L. (2019). Effects of probiotic supplementation on milk production, blood metabolite profile and enzyme activities of ewes during lactation. Italian Journal of Animal Science, 18(1), 134-139. DOI: 10.1080/1828051X.2018.1496040

Karabaliev, M., & Kochev, V. (2003). Interaction of solid supported thin lipid films with saponin. Sensors and Actuators B: Chemical, 88(1), 101-105. DOI: 10.1016/S0925-4005(02)00311-8

Kholif, A. E. (2023). A review of effect of saponins on ruminal fermentation, health and performance of ruminants. Veterinay Science, 10, e450. DOI: 10.3390/vetsci10070450

Khudadad, J. I., Hatem, M. S., Jawad, W. A., Obaid, A. A., & Kamil, A. M. (2025). Assessed investigation on the Cyprian weaned goats' body size and mass after the propolis inclusion. International Journal of Veterinary Sciences and Animal Husbandry, 10(5): 246-251. DOI: 10.22271/veterinary.2025.v10.i5d.2270

Kim, E. Y., Kim, Y. H., Rhee, M. H., Song, J. C., Lee, K. W., Kim, K. S., Lee S.P., Lee I. S. & Parque, S. C. (2007). Selection of Lactobacillus sp. PSC101 that produces active dietary enzymes such as amylase, lipase, phytase and protease in pigs. The Journal of General and Applied Microbiology, 53(2), 111-117. DOI: 10.2323/jgam.53.111

Kholif, A. E., Anele, A., & Uchenna Y. (2024). Anele. Microbial feed additives in ruminant feeding. AIMS Microbiology, 10(3): 542–571. DOI: 10.3934/microbiol.2024026

Khudadad, J. I., Hatem, M. S., Jawad, W. A., Obaid A. A., & Kamil, A. M. (2025). Assessed investigation on the Cyprian weaned goats' body size and mass after the propolis inclusion. International Journal of Veterinary Sciences and Animal Husbandry, 10(5), 246-251. DOI: 10.22271/veterinary.2025.v10.i5d.2270

Kulkarni, N. A., Chethan, H. S., Srivastava, R., & Gabbur, A. B. (2022). Role of probiotics in ruminant nutrition as natural modulators of health and productivity of animals in tropical countries: an overview. Tropical Animal Health and Production, 54(2), 110. DOI: 10.1007/s11250-022-03112-y

Li, W., & Powers, W. (2012). Effects of saponin extracts on air emissions from steers. Journal of Animal Science, 90(11), 4001-4013. DOI: 10.2527/jas.2011-4888

Li, T., Raja, B. R., Liao, J., Zheng, L., Yin, F., Gan, S., Sun, X., Lyu, G., & Ma, J. (2025). The characteristics, influence factors, and regulatory strategies of growth retardation in ruminants: a review. Frontiers in Veterinary Science, 12, e1566427. DOI: 10.3389/fvets.2025.1566427

Mahesh, M. S., Mohanta, R. K., & Patra, A. K. (2021). Probiotics in livestock and poultry nutrition and health. In G. Goel & A. Kumar (orgs.), Advances in Probiotics for Sustainable Food and Medicine (149–179). Springer Singapore. DOI: 10.1007/978-981-15-6795-7_7

MAPA. (2004). Ministério da Agricultura, Pecuária e Abastecimento. Regulamento técnico sobre o uso de aditivos para produtos destinados à alimentação animal. Instrução Normativa n° 13/2004. Disponível em: https://www.gov.br/agricultura/pt-br/assuntos/insumos-agropecuarios/insumos-pecuarios/alimentacao-animal/aditivos. Acesso: 15 de setembro de 2025.

Markowiak, P., & Śliżewska, K. (2018). The role of probiotics, prebiotics and synbiotics in animal nutrition. Gut Pathogens, 10, 1-20. DOI: 10.1186/s13099-018-0250-0

Marques, R. D. S., & Cooke, R. F. (2021). Effects of ionophores on ruminal function of beef cattle. Animals, 11(10), 2871. DOI: 10.3390/ani11102871

Marrone, G., Di Lauro, M., Izzo, F., Cornali, K., Masci, C., Vita, C., Occhiuto, F., Di Daniele, N., De Lorenzo, A., & Noce, A. (2024). Possible beneficial effects of hydrolyzable tannins deriving from Castanea sativa L. in internal medicine. Nutrients, 16, e45. DOI: 10.3390/nu16010045

Meade, E., Slattery, M. A., & Garvey, M. (2020). Bacteriocins, potent antimicrobial peptides and the fight against multi drug resistant species: resistance is futile? Antibiotics, 9(1), 32. DOI: 10.3390/antibiotics9010032

Min, B. R., Attwood, G. T., McNabb, W. C., Molan, A. L., & Barry, T. N. (2005). The effect of condensed tannins from Lotus corniculatus on the proteolytic activities and growth of rumen bacteria. Animal Feed Science and Technology, 121(1-2), 45-58. DOI: 10.1016/j.anifeedsci.2005.02.007

Minamikawa, M., Kawai, Y., Inoue, N., & Yamazaki, K. (2005). Purification and characterization of warnericin RB4, anti-Alicyclobacillus bacteriocin, produced by Staphylococcus warneri RB4. Current Microbiology, 51, 22-26. DOI: 10.1007/s00284-005-4456-2

Mousa, S., Elsayed, A., Marghani, B., & Ateya, A. (2019). Effects of supplementation of Bacillus spp. on blood metabolites, antioxidant status, and gene expression pattern of selective cytokines in growing Barki lambs. Journal of Advanced Veterinary and Animal Research, 6(3), 333–340.

Nabgan, M., Shariatifar, N., & Zeinali, T. (2025). Comparative investigation of Mycotoxin detoxification mechanisms by lactic acid bacteria (Lactobacillus species) and non-lactic acid bacteria. Journal of Food Measurement and Characterization, 19, 3839–3866. DOI: 10.1007/s11694-025-03259-w

Nagaraja, T. G. & Taylor, M. B. (1987). Susceptibility and resistance of ruminal bacteria to antimicrobial feed additives. Applied and Environmental Microbiology, 53(7), 1620-1625. DOI: 10.1128/aem.53.7.1620-1625.1987

Naumann, H. D., Tedeschi, L. O., Zeller, W. E., & Huntley, N. F. (2017). The role of condensed tannins in ruminant animal production: advances, limitations and future directions. Revista Brasileira de Zootecnia, 46(12), 929-949. DOI: 10.1590/S1806-92902017001200009

Negash, A. W., & Tsehai, B. A. (2020). Current applications of bacteriocin. International Journal of Microbiology, 2020(1), e4374891. DOI: 10.1155/2020/4374891

Neiva, M. C., Schultz, E. B., Sousa, L. M., Oliveira, K. A., Sousa, L. F., & Macedo Junior, G. L. (2022). Exogenous enzymes in sheep diet: nutritional and physiological parameters. Acta Scientiarum. Animal Sciences, 44, e56504. DOI: 10.4025/actascianimsci.v44i1.56504

Newbold, C. J., & Hillman, K. (1990). The effect of ciliate protozoa on the turnover of bacterial and fungal protien in the rumen of sheep. Letters in applied Microbiology, 11(2), 100-102. DOI: 10.1111/j.1472-765X.1990.tb01286.x

Oliveira, K. A., Assis, T. S., Sousa, L., Siqueira, M. T. S., Souza, A. M., & Macedo Júnior G. L. M. (2020). Consumo de nutrientes, comportamento ingestivo e parâmetros fisiológicos de ovinos alimentados com volumoso extrusado contendo diferentes aditivos. Caderno de Ciências Agrárias, 12, 1-9. DOI: 10.35699/2447-6218.2020.20606

Pandey, A.K., Kumar, P., Saxena, M. J. (2019). Feed Additives in Animal Health. In: R. Gupta, A. Srivastava, & R. Lall (orgs.), Nutraceuticals in Veterinary Medicine (345-362) Springer Cham. DOI: 10.1007/978-3-030-04624-8_23

Patra, A. K., & Saxena, J. (2010). A new perspective on the use of plant secondary metabolites to inhibit methanogenesis in the rumen. Phytochemistry, 71, 1198–1222. DOI:10.1016/j.phytochem.2010.05.010

Possamai, A., Lala, B., Pereira, V., Gomes, L., & Silva, S. (2011). Modificadores da fermentação ruminal: uma revisão. Revista Brasileira de Engenharia de Biossistemas, 5(2), 108-116. DOI: 10.18011/bioeng2011v5n2p108-116

Rachwał, K., & Gustaw, K. (2024). Lactic acid bacteria in sustainable food production. Sustainability, 16(8), e3362. DOI: 10.3390/su16083362

Raheem, K. A., Basiru, A., Raji, L. O., & Odetokun, I. A. (2024). Productive performance of goat. Trends in Clinical Diseases, Production and Management of Goats, 1, 163-177. DOI: 10.1016/B978-0-443-23696-9.00001-8

Rashwan, A. K., Osman, A. I., Abdelshafy, A. M., Mo, J., & Chen, W. (2025). Plant-based proteins: advanced extraction technologies, interactions, physicochemical and functional properties, food and related applications, and health benefits. Critical Reviews in Food Science and Nutrition, 65(4), 667-694. DOI: 10.1080/10408398.2023.2279696

Ren, Z., Yao, R., Liu, Q., Deng, Y., Shen, L., Deng, H., Zuo, Z., Wang, Y., Deng, J., Cui, H., Hu, Y., Ma, X. & Fang, J. (2019). Effects of antibacterial peptides on rumen fermentation function and rumen microorganisms in goats. PloS one, 14(8), e0221815. DOI: 10.1371/journal.pone.0221815

Saleem, A. A., Elaref, M. Y., Bassiony, S. M., Abdelnour, S. A., Helal, A. A., Abdel-Monem, U. M., & Al-Marakby, K. M. (2024) The effect of adding multi-strain probiotics (MSP) on the hematological, immunological and antioxidant parameters of male Saidi sheep. Egyptian Journal of Veterinary Sciences 1–8. 10.21608/ejvs.2024.294580.2143

Sanders, M. E., Merenstein, D. J., Reid, G., Gibson, G. R., & Rastall, R. A. (2019). Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature reviews Gastroenterology & Hepatology, 16(10), 605-616. DOI: 10.1038/s41575-019-0173-3

Santoso, B., Mwenya, B., Sar, C., Gamo, Y., Kobayashi, T., Morikawa, R., Kimura, K., Mizukoshi, H. & Takahashi, J. (2004). Effects of supplementing galacto-oligosaccharides, Yucca schidigera or nisin on rumen methanogenesis, nitrogen and energy metabolism in sheep. Livestock Production Science, 91(3), 209-217. DOI: 10.1016/j.livprodsci.2004.08.004

Sar, C., Mwenya, B., Pen, B., Morikawa, R., Takaura, K., Kobayashi, T., & Takahashi, J. (2005). Effect of nisin on ruminal methane production and nitrate/nitrite reduction in vitro. Australian Journal of Agricultural Research, 56(8), 803-810. DOI: 10.1071/AR04294

Schmitt, M. H., Ward, M. H. D., & Shrader, A. M. (2020). Salivary tannin-binding proteins: a foraging advantage for goats? Livestock Science, 234, 1–6. DOI: 10.1016/j. livsci.2020.103974.

Sevda, S., McClure, S. J. (2004). Potential applications of chitosan in veterinary medicine. Advanced Drug Delivery Reviews, 56(10), 1467-1480. DOI: 10.1016/j.addr.2004.02.007

Shurson, G. C. (2018). Yeast and yeast derivatives in feed additives and ingredients: Sources, characteristics, animal responses, and quantification methods. Animal Feed Science and Technology, 235, 60–76. DOI: 10.1016/j.anifeedsci.2017.11.010

Silva, A. P. R., Sant’ana, A. S., Nascimento, S. P. O., Barbosa, S. N., Miranda, A. L. A., Luna, F. S., Gois, G. C., Moraes, S. A., Rodrigues, R. T. S., Menezes, D. R. (2021). Tannins in the diet for lactating goats from different genetic groups in the Brazilian semiarid: Nitrogen, energy and water balance. Animal Feed Science and Technology, 279, e115023. DOI: 10.1016/j.anifeedsci.2021.115023

Soldado, D., Bessa, R. J., & Jerónimo, E. (2021). Condensed tannins as antioxidants in ruminants—Effectiveness and action mechanisms to improve animal antioxidant status and oxidative stability of products. Animals, 11(11), e3243. DOI: 10.3390/ani11113243

Soliman, S. M., El-Shinnawy, A. M., & El-Morsy, A. M. (2016). Effect of probiotic or prebiotic supplementation on the productive performance of Barki Lambs. Journal of Animal and Poultry Production, 7(10): 369- 376.

Stradiotti Júnior, D., Queiroz, A. C. D., Lana, R. D. P., Pacheco, C. G., Eifert, E. D. C., & Nunes, P. M. M. (2004). Ação da própolis sobre a desaminação de aminoácidos e a fermentação ruminal. Revista Brasileira de Zootecnia, 33, 1086-1092. DOI: 10.1590/S1516-35982004000400029

Terra-Braga, M., Poli, C. H., Tontini, J. F., Ahsin, M., Van Vliet, S., & Villalba, J. J. (2024). Trade-offs between selection of crude protein and tannins in growing lambs. Journal of Animal Science, 102, skae298. https://doi.org/10.1093/jas/skae298

Torres-Maravilla, E., Méndez-Trujillo, V., Hernández-Delgado, N. C., Bermúdez-Humarán, L. G., & Reyes-Pavón, D. (2022). Looking inside mexican traditional food as sources of synbiotics for developing novel functional products. Fermentation, 8(3), 123. DOI: 10.3390/fermentation8030123

Uyeno, Y., Shigemori, S., & Shimosato, T. (2015). Effect of probiotics/prebiotics on cattle health and productivity. Microbes and Environments, 30(2), 126-132. DOI: 10.1264/jsme2.ME14176

Van Hemert, S., Meijerink, M., Molenaar, D., Bron, P. A., De Vos, P., Kleerebezem, M., Wells, J. M. & Marco, M. L. (2010). Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells. BMC Microbiology, 10, 1-13. DOI: 10.1186/1471-2180-10-293

Varada, V. V., & Kumar, S. (2024). Scope of microbial feed additives in ruminant nutrition. In: M. S. Mahesh, & V. K. Yata (orgs). Feed Additives and Supplements for Ruminants (29-50). Springer Singapore. DOI: 10.1007/978-981-97-0794-2_2

Vieco-Saiz, N., Belguesmia, Y., Raspoet, R., Auclair, E., Gancel, F., Kempf, I., & Drider, D. (2019). Benefits and inputs from lactic acid bacteria and their bacteriocins as alternatives to antibiotic growth promoters during food-animal production. Frontiers in Microbiology, 10, e57. DOI: 10.3389/fmicb.2019.00057

Vieira, L. V., Schmidt, A. P., Barbosa, A. A., Feijó, J. O., Brauner, C. C., Rabassa, V. R., Corrêa, M. N., Schmitt, E., & Del Pino, F. A. B. (2020). Utilização de taninos como aditivo nutricional na dieta de ruminantes. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, 23(1), e2306.

Waghorn, G. (2008). Beneficial and detrimental effects of dietary condensed tannins for sustainable sheep and goat production-Progress and challenges. Animal Feed Science and Technology, 147(1-3), 116-139. DOI: 10.1016/j.anifeedsci.2007.09.013

Wanapat, M., Kang, S., & Polyorach, S. (2013). Development of feeding systems and strategies of supplementation to enhance rumen fermentation and ruminant production in the tropics. Journal of Animal Science and Biotechnology, 4, 1-11. DOI: 10.1186/2049-1891-4-32

Wang, J., Deng, L., Chen, M., Che, Y., Li, L., Zhu, L., Chen, G. & Feng, T. (2024). Phytogenic feed additives as natural antibiotic alternatives in animal health and production: A review of the literature of the last decade. Animal Nutrition, 17, 244-264. DOI: 10.1016/j.aninu.2024.01.012

Wang, Z., Guo, L., Ding, X., Li, F., Xu, H., Li, S., Wang, X., Li, K., & Yue, X. (2023). Supplementation of chestnut tannins in diets can improve meat quality and antioxidative capability in Hu lambs. Meat Science, 206, e109342. DOI: 10.1016/j.meatsci.2023.109342

Wang, C. J., Wang, S. P., & Zhou, H. (2009). Influences of flavomycin, ropadiar, and saponin on nutrient digestibility, rumen fermentation, and methane emission from sheep. Animal Feed Science and Technology, 148, 157–166. DOI: 10.1016/j.anifeedsci.2008.03.008

Weng, C., Peng, X., & Han, Y. (2021). Depolymerization and conversion of lignin to value-added bioproducts by microbial and enzymatic catalysis. Biotechnology for Biofuels, 14, 1-22. DOI: 10.1186/s13068-021-01934-w

Wina, E., Muetzel, S., & Becker, K. (2005). The impact of saponins or saponin-containing plant materials on ruminant production A Review. Journal of Agricultural and Food Chemistry, 53(21), 8093-8105. DOI: 10.1021/jf048053d

Yang, C., Zhang, T., Tian, Q., Cheng, Y., Gebeyew, K., Liu, G., Zhiliang Tan & He, Z. (2022). Supplementing mannan oligosaccharide reduces the passive transfer of immunoglobulin g and improves antioxidative capacity, immunity, and intestinal microbiota in neonatal goats. Frontiers in Microbiology, 12, e795081. DOI: 10.3389/fmicb.2021.795081

Yang, S. C., Lin, C. H., Sung, C. T., & Fang, J. Y. (2014). Antibacterial activities of bacteriocins: application in foods and pharmaceuticals. Frontiers in Microbiology, 5, e241. DOI: 10.3389/fmicb.2014.00241

Zhang, S.-W., Duan, C.-H., Zhang, X.-Y., Li, F., Guo, Y.-X., Ji, S.-K., Yan, H., Liu, Y.-Q., & Zhang, Y.-J. (2023). Effects of mannan oligosaccharide on feed intake, body weight and serum biochemical indexes of perinatal Hu sheep ewes. Chinese Journal of Animal Nutrition, 35(3), 1791-1802. DOI: 10.12418/CJAN2023.169

Zhang, Y., Choi, S. H., Nogoy, K. M., & Liang, S. (2021). The development of the gastrointestinal tract microbiota and intervention in neonatal ruminants. Animal, 15(8), e100316. DOI: 10.1016/j.animal.2021.100316

Zilio, E. M., Del Valle, T. A., Ghizzi, L. G., Takiya, C. S., Dias, M. S., Nunes, A. T., Silva, G. G. & Rennó, F. P. (2019). Effects of exogenous fibrolytic and amylolytic enzymes on ruminal fermentation and performance of mid-lactation dairy cows. Journal of Dairy Science, 102(5), 4179-4189. DOI: 10.3168/jds.2018-14949

Publicado

2026-03-21

Como Citar

Fernando Simão, J., Caique Félix Rodrigues, M., Batista Pereira, A., Oliveira da Silva, E., Karoline de Oliveira Aureliano, Érika, Costa Gois, G., … de Almeida Araújo, C. (2026). Uso de aditivos e compostos secundários na nutrição de caprinos e ovinos: revisão de literatura. Diversitas Journal, 11(1), 0239–0260. https://doi.org/10.48017/dj.v11i1.3624