Evolución de la investigación sobre hongos endófitos asociados a plantas: un análisis cienciométrico y bibliométrico (2015-2025)
DOI:
https://doi.org/10.48017/dj.v11i3.3956Palabras clave:
Interación simbiotica, analise multivariada, plantas hospederasResumen
Los hongos endófitos asociados a plantas han despertado un creciente interés científico debido a su relevancia ecológica y a su elevado potencial biotecnológico, especialmente para la producción de metabolitos bioactivos con aplicaciones agrícolas, farmacológicas y ambientales. Este estudio tuvo como objetivo analizar los patrones, las tendencias y las brechas en la producción científica sobre hongos endófitos asociados a plantas entre 2015 y 2025, empleando un enfoque cienciométrico descriptivo. Se analizaron artículos indexados en la *Web of Science Core Collection*, seleccionados según criterios preestablecidos. Los datos se evaluaron mediante estadística descriptiva y análisis multivariantes, incluido el Análisis de Coordenadas Principales (PCoA). Los resultados mostraron un crecimiento continuo de la producción científica, concentrada en países como China, Brasil, India y Estados Unidos. Se observó un patrón asimétrico en la selección de familias botánicas hospedadoras, con un predominio de Poaceae, Fabaceae, Bignoniaceae, Meliaceae, Zingiberaceae y Asteraceae, lo que indica sesgos taxonómicos asociados a la relevancia económica y medicinal de dichas plantas. El PCoA demostró que la selección de familias botánicas sigue tendencias científicas y dinámicas temporales a lo largo del periodo analizado. Se concluye que, si bien el campo está consolidado, ampliar el alcance taxonómico y geográfico de las investigaciones resulta fundamental para reducir las brechas de conocimiento y potenciar el descubrimiento de nuevos hongos endófitos y metabolitos bioactivos.
Citas
Adeleke, B. S., & Babalola, O. O. (2021). Pharmacological potential of fungal endophytes associated with medicinal plants: A review. Journal of Fungi, 7(2), 147. https://doi.org/10.3390/jof7020147
Ancheeva, E., Daletos, G., & Proksch, P. (2020). Bioactive secondary metabolites from endophytic fungi. Current Medicinal Chemistry, 27(11), 1836–1854. https://doi.org/10.2174/0929867326666190916144709
Ansabayeva, A., Makhambetov, M., Rebouh, N. Y., Abdelkader, M., Saudy, H. S., Hassan, K. M., Nasser, M. A., Ali, M. A. A., & Ebrahim, M. (2025). Plant growth-promoting microbes for resilient farming systems: Mitigating environmental stressors and boosting crops productivity—A review. Horticulturae, 11(3), 260. https://doi.org/10.3390/horticulturae11030260
Baron, N. C., & Rigobelo, E. C. (2022). Endophytic fungi: A tool for plant growth promotion and sustainable agriculture. Mycology, 13(1), 39–55. https://doi.org/10.1080/21501203.2021.1945699
Bezerra, V. H. S., Cardoso, S. L., Fonseca-Bazzo, Y., Silveira, D., Magalhães, P. O., & Souza, P. M. (2021). Protease produced by endophytic fungi: A systematic review. Molecules, 26(22), 7062. https://doi.org/10.3390/molecules26227062
Bogas, A. C., Cruz, F. P. N., Lacava, P. T., & Sousa, C. P. (2024). Endophytic fungi: An overview on biotechnological and agronomic potential. Brazilian Journal of Biology, 84, e258557. https://doi.org/10.1590/1519-6984.258557
Coertjens, N. C., Mascarenhas, M. S., & Batistote, M. (2024). Brazilian endophytic fungi: Biotechnological potential in evidence. Diversitas Journal, 9(3), 1253–1266. https://doi.org/10.48017/dj.v9i3.2840
Devi, R., Verma, R., Dhalaria, R., Kumar, A., Kumar, D., Puri, S., Thakur, M., Chauhan, S., Chauhan, P. P., Nepovimova, E., & Kuca, K. (2023). A systematic review on endophytic fungi and its role in the commercial applications. Planta, 257(4), 70. https://doi.org/10.1007/s00425-023-04087-2
Dos Reis, J. B. A., Lorenzi, A. S., Pinho, D. B., Cortelo, P. C., & do Vale, H. M. M. (2024). The hidden treasures in endophytic fungi: A comprehensive review on the diversity of fungal bioactive metabolites, usual analytical methodologies, and applications. Archives of Microbiology, 206(4), 185. https://doi.org/10.1007/s00203-024-03911-x
Dos Reis, J. B. A., Pappas Junior, G. J., Lorenzi, A. S., Pinho, D. B., Costa, A. M., Bustamante, M. M. D. C., & do Vale, H. M. M. (2023). How deep can the endophytic mycobiome go? A case study on six woody species from the Brazilian Cerrado. Journal of Fungi, 9(5), 508. https://doi.org/10.3390/jof9050508
Dos Santos, I. R., Mohamed, T. A., Borges, L. L., Abo Nahas, H. H., Abdel-Azeem, M. A., Carvalho, D. D. C., Bezerra, J. P., Gupta, V. K., Xavier-Santos, S., Mossa, M. I., & Abdel-Azeem, A. M. (2022). The global tendency in the research of biological activity in endophytic fungi: A scientometric analysis. Current Research in Environmental & Applied Mycology, 12(1), 1–14. https://doi.org/10.5943/cream/12/1/1
Gakuubi, M. M., Munusamy, M., Liang, Z.-X., & Ng, S. B. (2021). Fungal endophytes: A promising frontier for discovery of novel bioactive compounds. Journal of Fungi, 7(10), 786. https://doi.org/10.3390/jof7100786
Gao, Y., Xu, Y., Dong, Z., Guo, Y., Luo, J., Wang, F., Yan, L., & Zou, X. (2025). Endophytic fungal diversity and its interaction mechanism with medicinal plants. Molecules, 30(5), 1028. https://doi.org/10.3390/molecules30051028
Goyal, J., Upadhayay, P., Talukdar, A. D., Yadav, P., Banerjee, P., Shakya, A., ... & Rai, N. (2025). Proteomics of Fungal Endophytes: Trends and Insight for Biotechnology. In Multi-omics Approach to Investigate Endophyte Diversity (pp. 33-72). Singapore: Springer Nature Singapore.
Guo, S., Ye, G., Liu, W., Liu, R., Liu, Z., & Ma, Y. (2024). Environmental factors drive the biogeographic pattern of Hippophae rhamnoides root endophytic fungal diversity in the arid regions of Northwest China. Journal of Fungi, 10(10), 679. https://doi.org/10.3390/jof10100679
Harman, G. E., Doni, F., Khadka, R. B., & Uphoff, N. (2021). Endophytic strains of Trichoderma increase plants’ photosynthetic capability. Journal of Applied Microbiology, 130(2), 529–546. https://doi.org/10.1111/jam.14368
Hashem, A. H., Attia, M. S., Kandil, E. K., Fawzi, M. M., Abdelrahman, A. S., Khader, M. S., Khodaira, M. A., Emam, A. E., Goma, M. A., & Abdelaziz, A. M. (2023). Bioactive compounds and biomedical applications of endophytic fungi: A recent review. Microbial Cell Factories, 22(1), 107. https://doi.org/10.1186/s12934-023-02118-x
Hu, A. G. Z. (2020). Public funding and the ascent of Chinese science: Evidence from the National Natural Science Foundation of China. Research Policy, 49(5), 103983. https://doi.org/10.1016/j.respol.2020.103983
Jha, P., Kaur, T., Chhabra, I., Panja, A., Paul, S., Kumar, V., & Malik, T. (2023). Endophytic fungi: Hidden treasure chest of antimicrobial metabolites interrelationship of endophytes and metabolites. Frontiers in Microbiology, 14, 1227830. https://doi.org/10.3389/fmicb.2023.1227830
Kumar, G., Chandra, P., & Choudhary, M. (2017). Endophytic fungi: A potential source of bioactive compounds. Chem. Sci. Rev. Lett, 6, 2373-2381.
Lee, S., Nguyen, Q. N., Phung, H. M., Shim, S. H., Kim, D., Hwang, G. S., & Kang, K. S. (2021). Preventive effects of anthraquinones isolated from an endophytic fungus, Colletotrichum sp. JS-0367 in tumor necrosis factor-α-stimulated damage of human dermal fibroblasts. Antioxidants, 10(2), 200. https://doi.org/10.3390/antiox10020200
Li, Q. X., Lin, F. C., & Su, Z. Z. (2025). Endophytic fungi—Big player in plant-microbe symbiosis. Current Plant Biology, 42, 100481. https://doi.org/10.1016/j.cpb.2025.100481
Majhi, P., Pradhan, U., Toppo, A., & Shukla, A. K. (2025). Fungal endophytes: An insight into diversity, stress tolerance, biocontrol and plant growth-promoting potentials. Current Microbiology, 82(6), 283. https://doi.org/10.1007/s00284-025-04266-2
Malicka, M., Magurno, F., & Piotrowska-Seget, Z. (2022). Plant association with dark septate endophytes: When the going gets tough (and stressful), the tough fungi get going. Chemosphere, 302, 134830. https://doi.org/10.1016/j.chemosphere.2022.134830
Manganyi, M. C., & Ateba, C. N. (2020). Untapped potentials of endophytic fungi: A review of novel bioactive compounds with biological applications. Microorganisms, 8(12), 1934. https://doi.org/10.3390/microorganisms8121934
Mattoo, A. J., & Nonzom, S. (2021). Endophytic fungi: Understanding complex cross-talks. Symbiosis, 83(3), 237–264. https://doi.org/10.1007/s13199-020-00744-2
Mayrhofer, B. F., Iantas, J., Noriler, S. A., Ponomareva, L. V., Thorson, J. S., Rohr, J., Shaaban, K. A., & Glienke, C. (2024). Highly diverse endophytic fungi from Serra do Amolar-Pantanal (Brazil) producing bioactive secondary metabolites against phytopathogens. Frontiers in Microbiology, 15, 1501182. https://doi.org/10.3389/fmicb.2024.1501182
Mendieta-Brito, S., Sayed, M., Hamza, F. A., Son, E., Kim, D. S., Plata, G., ... & Pyo, S. H. (2025). Identification, characterization, antimicrobial activity and biocontrol potential of four endophytic fungi isolated from Amazonian plants. Scientific Reports, 15(1), 39361.
Mulyani, Y., Sinaga, S. E., & Supratman, U. (2023). Phytochemistry and biological activities of endophytic fungi from the Meliaceae family. Molecules, 28(2), 778. https://doi.org/10.3390/molecules28020778
Noriler, S. A., Savi, D. C., Aluizio, R., Palácio-Cortes, A. M., Possiede, Y. M., & Glienke, C. (2018). Bioprospecting and structure of fungal endophyte communities found in the Brazilian biomes, Pantanal, and Cerrado. Frontiers in Microbiology, 9, 1526. https://doi.org/10.3389/fmicb.2018.01526
Papik, J., Folkmanova, M., Polivkova-Majorova, M., Suman, J., & Uhlik, O. (2020). The invisible life inside plants: Deciphering the riddles of endophytic bacterial diversity. Biotechnology Advances, 44, 107614. https://doi.org/10.1016/j.biotechadv.2020.107614
Prajapati, C., Rai, S. N., Singh, A. K., Chopade, B. A., Singh, Y., Singh, S. K., Haque, S., Prieto, M. A., & Ashraf, G. M. (2025). An update of fungal endophyte diversity and strategies for augmenting therapeutic potential of their potent metabolites: Recent advancement. Applied Biochemistry and Biotechnology, 197(5), 2799–2866. https://doi.org/10.1007/s12010-024-05098-9
Rai, N., Kumari Keshri, P., Verma, A., Kamble, S. C., Mishra, P., Barik, S., Kumar Singh, S., & Gautam, V. (2021). Plant associated fungal endophytes as a source of natural bioactive compounds. Mycology, 12(3), 139–159. https://doi.org/10.1080/21501203.2020.1870579
Ramatsitsi, N., & Manyevere, A. (2025). Roles of endophytic fungi in plant resilience under abiotic stress: A mechanistic review with implications for climate-smart agriculture. Plant Signaling & Behavior, 20(1), 2578712. https://doi.org/10.1080/15592324.2025.2578712
Santoyo, G. (2025). Advances in the plant microbiome: Rhizosphere, endosphere, and phyllosphere. Microorganisms, 13(11), 2581. https://doi.org/10.3390/microorganisms13112581
Satheesan, J., & Sabu, K. K. (2020). Endophytic fungi for a sustainable production of major plant bioactive compounds. In Plant-derived bioactives: Production, properties and therapeutic applications (pp. 195-207). Singapore: Springer Singapore.
Sena, L., Mica, E., Valè, G., Vaccino, P., & Pecchioni, N. (2024). Exploring the potential of endophyte-plant interactions for improving crop sustainable yields in a changing climate. Frontiers in Plant Science, 15, 1349401. https://doi.org/10.3389/fpls.2024.1349401
Sharma, S. B., Raverkar, K. P., Wani, S. P., Bagyaraj, D. J., Kannepalli, A., Kandula, D. R., ... & Sharma, R. (2025). Role of the Plant–Microbiome Partnership in Environmentally Harmonious 21st Century Agriculture. Microorganisms, 13(12), 2839.
Sharma, S., Dhar, M. K., & Kaul, S. (2023). Antagonistic, plant growth promoting and extracellular hydrolytic enzyme activity of fungal endophytes of Dioscorea bulbifera L. Biocatalysis and Agricultural Biotechnology, 50, 102694. https://doi.org/10.1016/j.bcab.2023.102694
Silva, R. M. F., Neto, W. P. P., Oliveira, R. J. V., Bezerra, J. D. P., Bezerra, J. L., de Lima, V. X., Vieira, L. C., Tabosa, J. N., Souza-Motta, C. M., & Silva, G. A. (2023). Effect of climate and phenological stage on fungal endophytes community in Sorghum bicolor leaves. Mycological Progress, 22(3), 19. https://doi.org/10.1007/s11557-023-01870-z
Singh, M., Naskar, A., Rupashree, A., Rajput, M., & Singh, V. K. (2023). Analysis of endophytic microbes harboring in medicinal plants of Himalayan region with their medicinal properties. Biocatalysis and Agricultural Biotechnology, 53, 102857. https://doi.org/10.1016/j.bcab.2023.102857
Stakelienė, V., Pašakinskienė, I., Matijošiūtė, S., Martūnas, J., & Štukėnienė, G. (2025). Identifying root-associated endophytic fungi and bacteria in Festuca and Lolium grasses from a site in Lithuania. Microorganisms, 13(4), 799. https://doi.org/10.3390/microorganisms13040799
Thangavel, M., Sneha, M. J. X., Mani, I., Surendrababu, A., Rajapriya, P., Arulselvan, P., Alarfaj, A. A., Thangavelu, I., & Pandi, M. (2025). Diversity of endophytic fungi in plant species: Traditional vs. high-throughput sequencing approaches. Chemistry & Biodiversity, e202402792. https://doi.org/10.1002/cbdv.202402792
Vandenkoornhuyse, P., Quaiser, A., Duhamel, M., Le Van, A., & Dufresne, A. (2015). The importance of the microbiome of the plant holobiont. New Phytologist, 206(4), 1196–1206. https://doi.org/10.1111/nph.13312
Verma, A., Shameem, N., Jatav, H. S., Sathyanarayana, E., Parray, J. A., Poczai, P., & Sayyed, R. Z. (2022). Fungal endophytes to combat biotic and abiotic stresses for climate-smart and sustainable agriculture. Frontiers in Plant Science, 13, 953836. https://doi.org/10.3389/fpls.2022.953836
Verma, V., Srivastava, A., Garg, S. K., Singh, V. P., & Arora, P. K. (2024). Incorporating omics-based tools into endophytic fungal research. Biotechnology Notes, 5, 1–7. https://doi.org/10.1016/j.biotno.2023.12.006
Wen, J., Okyere, S. K., Wang, S., Wang, J., Xie, L., Ran, Y., & Hu, Y. (2022). Endophytic fungi: An effective alternative source of plant-derived bioactive compounds for pharmacological studies. Journal of Fungi, 8(2), 205. https://doi.org/10.3390/jof8020205
Yadigarova, L. (2025). Bibliometric analysis of the impact of international research collaborations: Insights from social sciences. International Scientific Journal of Universities and Leadership, (19), 37–48. https://doi.org/10.31874/2520-6702-2025-19-37-48
Yan, L., Zhu, J., Zhao, X., Shi, J., Jiang, C., & Shao, D. (2019). Beneficial effects of endophytic fungi colonization on plants. Applied Microbiology and Biotechnology, 103(8), 3327–3340. https://doi.org/10.1007/s00253-019-09713-2
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2026 Maria do Socorro Mascarenhas, Gilberto José Arruda, Margareth Batistote
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
O periodico Diversitas Journal expressa que os artigos são de unica responsabilidade dos Autores, conhecedores da legislação Brasileira e internacional. Os artigos são revisados pelos pares e devem ter o cuidado de avisar da possível incidencia de plagiarismo. Contudo o plagio é uma ação incontestavel dos autores. A Diversitas Journal não publicará artigos com indicios de Plagiarismos. Artigos com plagios serão tratados em conformidade com os procedimentos de plagiarismo COPE.
A violação dos direitos autorais constitui crime, previsto no artigo 184, do Código Penal Brasileiro:
“Art. 184 Violar direitos de autor e os que lhe são conexos: Pena – detenção, de 3 (três) meses a 1 (um) ano, ou multa. § 1o Se a violação consistir em reprodução total ou parcial, com intuito de lucro direto ou indireto, por qualquer meio ou processo, de obra intelectual, interpretação, execução ou fonograma, sem autorização expressa do autor, do artista intérprete ou executante, do produtor, conforme o caso, ou de quem os represente: Pena – reclusão, de 2 (dois) a 4 (quatro) anos, e multa.”
