Brazilian endophytic fungi: biotechnological potential in evidence
DOI:
https://doi.org/10.48017/dj.v9i3.2840Keywords:
Biomes., Biological activity., Biodiversity., Pharmacological Properties.Abstract
Plants play a key role in the ecosystem, especially in interactions with other living beings, including endophytic fungi. These fungi have a remarkable ability to produce bioactive compounds that resemble those present in their host plants. In this context, this study aims to present an overview of research carried out in Brazil on the biotechnological potential of endophytic fungi isolated from plants present in different Brazilian biomes. To achieve this goal, exploratory research was conducted in online databases and in open access published articles. The results indicate a concentration of investigations on prospecting endophytic fungi with metabolic potential in the Cerrado, Caatinga and Pantanal biomes. These endophytic fungi have a vast potential for the production of biomolecules with diverse applications in biotechnological processes. Some of these fungi have the ability to produce metabolites with varied biological activities, including pharmacological properties, such as antitumor and antibiotics. However, it is important to note that these fungi are still poorly studied, and may be explored in relation to their potential for producing biomolecules.
Metrics
References
Abu Taher, M., Tong, W. Y., Leong, C. R., Ab Rashid, S., & Tan, W. N. (2023). General Characteristics of Endophytes and Bioprospecting Potential of Endophytic Fungi. Advancements in Materials Science and Technology Led by Women, 35-49. https://doi.org/10.1007/978-3-031-21959-7_4
Al Husnain, L., Alajlan, L., AlKahtani, M. D., & Ameen, F. (2023). Avicennia marina endophytic fungi shows antagonism against tomato pathogenic fungi. Journal of the Saudi Society of Agricultural Sciences, 22(4), 214-222. https://doi.org/10.1016/j.jssas.2022.12.001
Alves, D. R., da Silva, W. M. B., dos Santos, D. L., de Oliveira Freire, F. D. C., Vasconcelos, F. R., & de Morais, S. M. (2020). Atividades antioxidante, anticolinesterásica e citotóxica de metabólitos de fungos endofíticos. Brazilian Journal of Development, 6(9), 73684-73691. https://doi.org/10.34117/bjdv6n9-721
Andrioli, W. J., Simão, T. L. B. V., Ferreira, D. P., Araújo, M. H., Calixto, S. D., Bastos, J. K., ... & Muzitano, M. F. (2022). Antimycobacterial and anti-inflammatory activities of metabolites from endophytic and soil fungi. Phytomedicine Plus, 2(3), 100312. https://doi.org/10.1016/j.phyplu.2022.100312
Barbosa, R. D. N., Bezerra, J. D. P., Santos, A. C. D. S., Melo, R. F. R., Houbraken, J., Oliveira, N. T., & Souza-Motta, C. M. D. (2020). Brazilian tropical dry forest (Caatinga) in the spotlight: an overview of species of Aspergillus, Penicillium and Talaromyces (Eurotiales) and the description of P. vascosobrinhous sp. nov. Acta Botanica Brasilica, 34, 409-429. https://doi.org/10.1590/0102-33062019abb0411
Baron, N. C., & Rigobelo, E. C. (2022). Endophytic fungi: a tool for plant growth promotion and sustainable agriculture. Mycology, 13(1), 39-55. https://doi.org/10.1080/21501203.2021.1945699
Bolívar-Anillo, H. J., Garrido, C., & Collado, I. G. (2020). Endophytic microorganisms for biocontrol of the phytopathogenic fungus Botrytis cinerea. Phytochemistry Reviews, 19, 721-740. https://doi.org/10.1007/s11101-019-09603-5
Calixto, J. B. (2019). The role of natural products in modern drug discovery. Anais da Academia Brasileira de Ciências, 91. https://doi.org/10.1590/0001-3765201920190105
Chandra, H., Kumari, P., Bontempi, E., & Yadav, S. (2020). Medicinal plants: Treasure trove for green synthesis of metallic nanoparticles and their biomedical applications. Biocatalysis and Agricultural Biotechnology, 24, 101518. https://doi.org/10.1016/j.bcab.2020.101518
Cheng, Y., Liu, G., Li, Z., Zhou, Y., & Gao, N. (2022). Screening saikosaponin d (SSd)-producing endophytic fungi from Bupleurum scorzonerifolium Willd. World Journal of Microbiology and Biotechnology, 38(12), 242. https://doi.org/10.21203/rs.3.rs-1822474/v1
Custodio, V., Gonin, M., Stabl, G., Bakhoum, N., Oliveira, M. M., Gutjahr, C., & Castrillo, G. (2022). Sculpting the soil microbiota. The Plant Journal, 109(3), 508-522. https://doi.org/10.1111/tpj.15568
Dalmagro, H. J., De Souza, P. J., Engelbrehct, M. M., de Arruda, P. H., Sallo, F. D. S., Vourlitis, G. L., ... & Couto, E. G. (2022). Net carbon dioxide exchange in a hyperseasonal cattle pasture in the northern Pantanal wetland of Brazil. Agricultural and Forest Meteorology, 324, 109099. https://doi.org/10.1016/j.agrformet.2022.109099
Dantas, S. B. S., Alves, F. A. M., & Chapla, V. M. (2021). Chemical, diversity and biotechnological potential of endophytic fungi isolated from Brazilian Cerrado plants. Biota Neotropica, 21, e20201069. https://doi.org/10.1590/1676-0611-BN-2020-1069
De Andrade Vieira, É., Coêlho, J. G. S., Grisi, C. V. B., dos Santos, B. S., da Silva Júnior, J. C., Alcântara, M. A., ... & de Magalhães Cordeiro, A. M. T. (2022). Correlation and influence of antioxidant compounds of peels and pulps of different species of cacti from Brazilian Caatinga biome using principal component analysis. South African Journal of Botany, 147, 434-442. https://doi.org/10.1016/j.sajb.2022.02.005
De Lima, R. A., Oliveira, A. A., Pitta, G. R., de Gasper, A. L., Vibrans, A. C., Chave, J., ... & Prado, P. I. (2020). The erosion of biodiversity and biomass in the Atlantic Forest biodiversity hotspot. Nature communications, 11(1), 6347. https://doi.org/10.1038/s41467-020-20217-w
De Oliveira Amaral, A., e Ferreira, A. F. T. A. F., & da Silva Bentes, J. L. (2022). Fungal endophytic community associated with Hevea spp.: diversity, enzymatic activity, and biocontrol potential. Brazilian Journal of Microbiology, 53(2), 857-872. https://doi.org/10.1007/s42770-022-00709-1
De Oliveira Santana, J. C., & Simon, M. F. (2022). Plant diversity conservation in an agricultural frontier in the Brazilian Cerrado. Biodiversity and Conservation, 31(2), 667-681. https://doi.org/10.1007/s10531-022-02356-2
De Oliveira, D. M., Pereira, C. B., Mendes, G., Junker, J., Kolloff, M., Rosa, L. H., ... & Cota, B. B. (2018). Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp. Zeitschrift für Naturforschung C, 73(11-12), 449-455. https://doi.org/10.1515/znc-2017-0162
De Paula, L. F., Azevedo, L. O., Mauad, L. P., Cardoso, L. J. T., Braga, J. M. A., Kollmann, L. J., ... & Forzza, R. C. (2020). Sugarloaf Land in south-eastern Brazil: a tropical hotspot of lowland inselberg plant diversity. Biodiversity Data Journal, 8. https://doi.org/10.3897/BDJ.8.e53135
Do Nascimento Magalhães, K., Guarniz, W. A. S., Sá, K. M., Freire, A. B., Monteiro, M. P., Nojosa, R. T., ... & Bandeira, M. A. M. (2019). Medicinal plants of the Caatinga, northeastern Brazil: Ethnopharmacopeia (1980–1990) of the late professor Francisco José de Abreu Matos. Journal of ethnopharmacology, 237, 314-353. https://doi.org/10.1016/j.jep.2019.03.032
Fenibo, E. O., Ijoma, G. N., & Matambo, T. (2021). Biopesticides in sustainable agriculture: A critical sustainable development driver governed by green chemistry principles. Frontiers in Sustainable Food Systems, 5, 619058. https://doi.org/10.3389/fsufs.2021.619058
Fernandes, G. W., Oki, Y., Belmiro, M. S., Resende, F. M., Corrêa Junior, A., & de Azevedo, J. L. (2018). Multitrophic interactions among fungal endophytes, bees, and Baccharis dracunculifolia: resin tapering for propolis production leads to endophyte infection. Arthropod-Plant Interactions, 12, 329-337. https://doi.org/10.1007/s11829-018-9597-x
Fernandes, M. F., Cardoso, D., & de Queiroz, L. P. (2020). An updated plant checklist of the Brazilian Caatinga seasonally dry forests and woodlands reveals high species richness and endemism. Journal of Arid environments, 174, 104079. https://doi.org/10.1016/j.jaridenv.2019.104079
Ferreira, G. W., & Reboita, M. S. (2022). A new look into the South America precipitation regimes: Observation and Forecast. Atmosphere, 13(6), 873. https://doi.org/10.3390/atmos13060873
Gonçalves, S., & Romano, A. (2018). Production of plant secondary metabolites by using biotechnological tools. Secondary metabolites-sources and applications, 5, 81-99. https://doi.org/ 10.5772/intechopen.76414
Gupta, S., Chaturvedi, P., Kulkarni, M. G., & Van Staden, J. (2020). A critical review on exploiting the pharmaceutical potential of plant endophytic fungi. Biotechnology Advances, 39, 107462. https://doi.org/10.1016/j.biotechadv.2019.107462
Hashem, A. H., Attia, M. S., Kandil, E. K., Fawzi, M. M., Abdelrahman, A. S., Khader, M. S., ... & Abdelaziz, A. M. (2023). Bioactive compounds and biomedical applications of endophytic fungi: a recent review. Microbial Cell Factories, 22(1), 1-23. https://doi.org/10.1186/s12934-023-02118-x
Hassane, A. M., Taha, T. M., Awad, M. F., Mohamed, H., & Melebari, M. (2022). Radical scavenging potency, HPLC profiling and phylogenetic analysis of endophytic fungi isolated from selected medicinal plants of Saudi Arabia. Electronic Journal of Biotechnology, 58, 37-45. https://doi.org/10.1016/j.ejbt.2022.05.001
Júnior, D. P. L., Dantas, E. S. D. O., Souza, R. D., Souza, M. H. D., Ramos, L. H. D., Sehn, M., ... & Silva, A. M. A. (2021). Burning Season: Challenges to Conserve Biodiversity and the Critical Points of a Planet Threatened by the Danger Called Global Warming. International Journal of Environment and Climate Change, 11(5), 60-90.
Kuila, D., & Ghosh, S. (2022). Aspects, problems and utilization of Arbuscular Mycorrhizal (AM) application as bio-fertilizer in sustainable agriculture. Current Research in Microbial Sciences, 3, 100107. https://doi.org/10.1016/j.crmicr.2022.100107
Kumar, V., Ahluwalia, V., Saran, S., Kumar, J., Patel, A. K., & Singhania, R. R. (2021). Recent developments on solid-state fermentation for production of microbial secondary metabolites: Challenges and solutions. Bioresource Technology, 323, 124566. https://doi.org/10.1016/j.biortech.2020.124566
Kuriakose, G. C., Arathi, B. P., Divya Lakshmanan, M., Jiby, M. V., Gudde, R. S., & Jayabhaskaran, C. (2020). Sub-acute toxicity assessment of taxol isolated from Fusarium solani, an endophytic fungus of Taxus brevifolia, in wistar rats and analyzing its cytotoxicity and apoptotic potential in lung cancer cells. Frontiers in Oncology, 10, 538865. https://doi.org/10.3389/fonc.2020.538865
Leite, P. M., Camargos, L. M., & Castilho, R. O. (2021). Recent progess in phytotherapy: A Brazilian perspective. European Journal of Integrative Medicine, 41, 101270. https://doi.org/10.1016/j.eujim.2020.101270
Liu, R., Yang, L., Zou, Y., & Wu, Q. (2023). Root-associated endophytic fungi modulate endogenous auxin and cytokinin levels to improve plant biomass and root morphology of trifoliate orange. Horticultural Plant Journal, 9(3), 463-472. https://doi.org/10.1016/j.hpj.2022.08.009
Losi, A., & Gaertner, W. (2021). A light life together: photosensing in the plant microbiota. Photochemical & Photobiological Sciences, 20(3), 451-473. https://doi.org/10.1007/s43630-021-00029-7
Magnusson, W. E., Grelle, C. E., Marques, M. C., Rocha, C. F., Dias, B., Fontana, C. S., ... & Fernandes, G. W. (2018). Effects of Brazil's political crisis on the science needed for biodiversity conservation. Frontiers in Ecology and Evolution, 6, 163. https://doi.org/10.3389/fevo.2018.00163
Maksic, J., Venancio, I. M., Shimizu, M. H., Chiessi, C. M., Piacsek, P., Sampaio, G., ... & Alexandre, F. F. (2022). Brazilian biomes distribution: Past and future. Palaeogeography, Palaeoclimatology, Palaeoecology, 585, 110717. https://doi.org/10.1016/j.palaeo.2021.110717
Manhães, A. P., Loyola, R., Mazzochini, G. G., Ganade, G., Oliveira-Filho, A. T., & Carvalho, A. R. (2018). Low-cost strategies for protecting ecosystem services and biodiversity. Biological Conservation, 217, 187-194. https://doi.org/10.1016/j.biocon.2017.11.009
Marinho, F., Oehl, F., da Silva, I. R., Coyne, D., da Nobrega Veras, J. S., & Maia, L. C. (2019). High diversity of arbuscular mycorrhizal fungi in natural and anthropized sites of a Brazilian tropical dry forest (Caatinga). Fungal Ecology, 40, 82-91. https://doi.org/10.1016/j.funeco.2018.11.014
Martinelli, L. A., Nardoto, G. B., Soltangheisi, A., Reis, C. R. G., Abdalla-Filho, A. L., Camargo, P. B. D., ... & Vieira, S. A. (2021). Determining ecosystem functioning in Brazilian biomes through foliar carbon and nitrogen concentrations and stable isotope ratios. Biogeochemistry, 154, 405-423. https://doi.org/10.1007/s10533-020-00714-2
Martins da Costa, E., Almeida Ribeiro, P. R., Soares de Carvalho, T., Pereira Vicentin, R., Balsanelli, E., Maltempi de Souza, E., ... & de Souza Moreira, F. M. (2020). Efficient nitrogen-fixing bacteria isolated from soybean nodules in the semi-arid region of Northeast Brazil are classified as Bradyrhizobium brasilense (Symbiovar sojae). Current Microbiology, 77(8), 1746-1755. https://doi.org/10.1007/s00284-020-01993-6
Pacheco-Tapia, R., Vásquez-Ocmín, P., Duthen, S., Ortiz, S., Jargeat, P., Amasifuen, C., ... & Vansteelandt, M. (2022). Chemical modulation of the metabolism of an endophytic fungal strain of Cophinforma mamane using epigenetic modifiers and amino-acids. Fungal Biology, 126(5), 385-394. https://doi.org/10.1016/j.funbio.2022.02.005
Palmatier, R. W., Houston, M. B., & Hulland, J. (2018). Review articles: purpose, process, and structure. Journal of the Academy of Marketing Science, 46, 1-5. https://doi.org/10.1007/s11747-017-0563-4
Raimi, A., & Adeleke, R. (2021). Bioprospecting of endophytic microorganisms for bioactive compounds of therapeutic importance. Archives of Microbiology, 203(5), 1917-1942. https://doi.org/10.1007/s00203-021-02256-z
Rutkowska, N., Drożdżyński, P., Ryngajłło, M., & Marchut-Mikołajczyk, O. (2023). Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds. International Journal of Molecular Sciences, 24(12), 10096. https://doi.org/10.3390/ijms241210096
Sharma, G., Agarwal, S., Verma, K., Bhardwaj, R., & Mathur, V. (2023). Therapeutic compounds from medicinal plant endophytes: molecular and metabolic adaptations. Journal of Applied Microbiology, lxad074. https://doi.org/10.1093/jambio/lxad074
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of business research, 104, 333-339. https://doi.org/10.1016/j.jbusres.2019.07.039
Soumare, A., Diedhiou, A. G., Thuita, M., Hafidi, M., Ouhdouch, Y., Gopalakrishnan, S., & Kouisni, L. (2020). Exploiting biological nitrogen fixation: a route towards a sustainable agriculture. Plants, 9(8), 1011. https://doi.org/10.3390/plants9081011
Trivedi, P., Leach, J. E., Tringe, S. G., Sa, T., & Singh, B. K. (2020). Plant–microbiome interactions: from community assembly to plant health. Nature Reviews Microbiology, 18(11), 607-621. https://doi.org/10.1038/s41579-020-0412-1
Uroz, S., Courty, P. E., & Oger, P. (2019). Plant symbionts are engineers of the plant-associated microbiome. Trends in plant science, 24(10), 905-916. https://doi.org/10.1016/j.tplants.2019.06.008
Valli, M., Russo, H. M., & Bolzani, V. S. (2018). The potential contribution of the natural products from Brazilian biodiversity to bioeconomy. Anais da Academia Brasileira de Ciências, 90, 763-778. https://doi.org/10.1590/0001-3765201820170653
Valli, M., & Bolzani, V. S. (2019). Natural products: perspectives and challenges for use of Brazilian plant species in the bioeconomy. Anais da Academia Brasileira de Ciências, 91. https://doi.org/10.1590/0001-3765201920190208
Vasundhara, M., Reddy, M. S., & Kumar, A. (2019). Secondary metabolites from endophytic fungi and their biological activities. New and future developments in microbial biotechnology and bioengineering, 237-258. https://doi.org/10.1016/B978-0-444-63504-4.00018-9
Xiao, Y., & Watson, M. (2019). Guidance on conducting a systematic literature review. Journal Of Planning Education And Research, 39(1), 93-112. https://doi.org/10.1177/0739456X17723971
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Nicole Carneiro Coertjens, Maria do Socorro Mascarenhas, Margareth Batistote
This work is licensed under a Creative Commons Attribution 4.0 International License.
The Diversitas Journal expresses that the articles are the sole responsibility of the Authors, who are familiar with Brazilian and international legislation.
Articles are peer-reviewed and care should be taken to warn of the possible incidence of plagiarism. However, plagiarism is an indisputable action by the authors.
The violation of copyright is a crime, provided for in article 184 of the Brazilian Penal Code: “Art. 184 Violating copyright and related rights: Penalty - detention, from 3 (three) months to 1 (one) year, or fine. § 1 If the violation consists of total or partial reproduction, for the purpose of direct or indirect profit, by any means or process, of intellectual work, interpretation, performance or phonogram, without the express authorization of the author, the performer, the producer , as the case may be, or whoever represents them: Penalty - imprisonment, from 2 (two) to 4 (four) years, and a fine. ”
.png){kind=logo}
